Description
Basic introduction
Semax is a synthetic heptapeptide based on an ACTH-derived fragment with a Pro-Gly-Pro extension. The XA5 and SX5 entries in this catalog are separate listings of the same named research compound, with their own available package options.
Preclinical studies have explored neurotrophin-related responses and gene expression in rodent brain preparations. These studies describe molecular and experimental endpoints; they are not evidence that a laboratory vial improves memory, mood or recovery in people.
Mechanism of action · Research context
ACTH-derived sequence
Semax is a defined seven-amino-acid peptide. Its relationship to an ACTH fragment provides a structural starting point, but should not be taken to mean that it reproduces all actions of intact ACTH.
BDNF-related responses
Rat hippocampal studies measured BDNF-related changes after Semax exposure. Researchers examined both transcript and protein-related endpoints, which capture different stages of a cellular response.
TrkB signaling
Neurotrophin signaling includes receptor activation as well as expression. The cited study examined TrkB phosphorylation, illustrating why an mRNA change alone is insufficient to characterize a signaling pathway.
Extended research considerations
Experimental context
Brain region, model and sampling time affect interpretation. A result from hippocampal tissue cannot automatically be assigned to every neuronal population or to a different injury model.
Sequence and batch comparison
Compare XA5 and SX5 by their actual documentation and selected package. Different catalog codes do not establish a biological difference, and identical names do not replace confirmation of batch identity.
Readout selection
Gene expression, protein abundance and functional behavior are distinct outcomes. A study plan should specify which of these it measures before interpreting a result as a broader neuronal effect.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 5 mg × 10 vials; 10 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at -20°C (Protect from light and moisture). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- Semax, BDNF and TrkB in rat hippocampal research
View report
Bryony R. –
A lab assistant accidentally left an unopened Semax vial out at room temperature for 4 full days. Upon testing, the powder had compacted into hard clumps and displayed drastically reduced neuroprotective activity, highlighting how non-negotiable strict dark frozen storage is for this peptide.
Caspian Niles –
Beyond rodent cognitive trials, I run primary cerebral neuron cell culture with SX5. Mild acetate buffer blends with all serum-free neural media, cutting daily pre-test prep time in half. Signaling data far more consistent than cheap generic Semax.
Daisie Oakley –
I run comparative dose-response brain cell trials, SX5’s consistent purity across all vials removes potency shifts that mess up comparison data. Test results from tiny dry powder scrapings align perfectly with full-vial mixed liquid tests, saving me hours recalibrating lab equipment between trial batches.
Lila Jett –
All international shipments use segmented foam dividers to separate each glass vial. Four cross-border orders completed, zero cracked, leaking or contaminated bottles. Insulated packaging holds steady low transit temperatures.
Quinn Sloat –
Gradient comparison trials use both 5mg and 10mg vials, purity consistent across both sizes. Dry powder sample data aligns with full reconstitution results, reducing equipment recalibration hours.