Description
Basic introduction
Semax is a synthetic heptapeptide based on an ACTH-derived fragment with a Pro-Gly-Pro extension. The XA5 and SX5 entries in this catalog are separate listings of the same named research compound, with their own available package options.
Preclinical studies have explored neurotrophin-related responses and gene expression in rodent brain preparations. These studies describe molecular and experimental endpoints; they are not evidence that a laboratory vial improves memory, mood or recovery in people.
Mechanism of action · Research context
ACTH-derived sequence
Semax is a defined seven-amino-acid peptide. Its relationship to an ACTH fragment provides a structural starting point, but should not be taken to mean that it reproduces all actions of intact ACTH.
BDNF-related responses
Rat hippocampal studies measured BDNF-related changes after Semax exposure. Researchers examined both transcript and protein-related endpoints, which capture different stages of a cellular response.
TrkB signaling
Neurotrophin signaling includes receptor activation as well as expression. The cited study examined TrkB phosphorylation, illustrating why an mRNA change alone is insufficient to characterize a signaling pathway.
Extended research considerations
Experimental context
Brain region, model and sampling time affect interpretation. A result from hippocampal tissue cannot automatically be assigned to every neuronal population or to a different injury model.
Sequence and batch comparison
Compare XA5 and SX5 by their actual documentation and selected package. Different catalog codes do not establish a biological difference, and identical names do not replace confirmation of batch identity.
Readout selection
Gene expression, protein abundance and functional behavior are distinct outcomes. A study plan should specify which of these it measures before interpreting a result as a broader neuronal effect.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 5 mg × 10 vials; 10 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at -20°C (Protect from light and moisture). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- Semax, BDNF and TrkB in rat hippocampal research
View report
Ewan N. –
I have purchased Semax from many different suppliers, and this batch is far purer. The powder stays bright white inside the vial and dissolves smoothly with gentle swirling, so I don’t need to shake harshly and risk damaging the peptide chain.
Elena Hogue –
University audits require individual HPLC certificates per vial. Support sent full chromatograms within 24h, all samples hit ≥99% purity and cut extra control testing steps entirely.
Vada Quinton –
A new trainee put an SX5 vial in a freezer zone with frequent temperature swings for two days. Follow-up tests showed heavy loss of biological activity, reminding me to strictly follow stable -20°C dark storage rules. I posted clear handling guides above my peptide shelf to avoid repeat mistakes.
Finnley G. –
This SX5 Semax is sterile acetate-buffered white lyophilized peptide powder with HPLC purity hitting ≥99%. Long-term preservation demands sealed vials stored at -20°C and fully shielded from light and humidity. Constant dark frozen storage stabilizes its short amino acid chain completely, avoiding hydrolysis and loss of neuroprotective activity for months of cognitive pathway research storage.
Jasper Hale –
I focus on cerebral blood flow cell testing, SX5 keeps all my dose-response curves smooth and reliable. Uniform potency means I never need to adjust dosing amounts mid-experiment. Bulk 10-vial packs cost much less than buying single vials separately for my regular testing cycles.