Description
Basic introduction
Semax is a synthetic heptapeptide based on an ACTH-derived fragment with a Pro-Gly-Pro extension. The XA5 and SX5 entries in this catalog are separate listings of the same named research compound, with their own available package options.
Preclinical studies have explored neurotrophin-related responses and gene expression in rodent brain preparations. These studies describe molecular and experimental endpoints; they are not evidence that a laboratory vial improves memory, mood or recovery in people.
Mechanism of action · Research context
ACTH-derived sequence
Semax is a defined seven-amino-acid peptide. Its relationship to an ACTH fragment provides a structural starting point, but should not be taken to mean that it reproduces all actions of intact ACTH.
BDNF-related responses
Rat hippocampal studies measured BDNF-related changes after Semax exposure. Researchers examined both transcript and protein-related endpoints, which capture different stages of a cellular response.
TrkB signaling
Neurotrophin signaling includes receptor activation as well as expression. The cited study examined TrkB phosphorylation, illustrating why an mRNA change alone is insufficient to characterize a signaling pathway.
Extended research considerations
Experimental context
Brain region, model and sampling time affect interpretation. A result from hippocampal tissue cannot automatically be assigned to every neuronal population or to a different injury model.
Sequence and batch comparison
Compare XA5 and SX5 by their actual documentation and selected package. Different catalog codes do not establish a biological difference, and identical names do not replace confirmation of batch identity.
Readout selection
Gene expression, protein abundance and functional behavior are distinct outcomes. A study plan should specify which of these it measures before interpreting a result as a broader neuronal effect.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 5 mg × 10 vials; 10 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at -20°C (Protect from light and moisture). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- Semax, BDNF and TrkB in rat hippocampal research
View report
Elena Vale –
My long-duration cognitive decline rodent trials run continuously for multiple months, and every new SX5 shipment matches the exact purity and potency of prior batches. The loose lyophilized powder never compacts into hard sediment at the vial base. I scrape tiny dry powder aliquots for micro screening tests instead of dissolving the entire 5mg vial, greatly stretching each kit’s usable supply.
Zara Sloan –
My university research lab is required to submit individual HPLC purity documentation for every vial for institutional audits and academic paper publications. Customer support delivered unique certified chromatogram reports for each bottle within a 24-hour window. All samples registered above 99% purity with no unidentified impurity peaks, so I eliminated redundant control validation assays.
Elara V. –
Every vial inside the 5mg×10 bulk kit holds ultra-fine uniform white lyophilized powder that dissolves instantly into particle-free clear aqueous liquid. The airtight gold aluminum crimp cap creates a full moisture barrier, so the powder never clumps even after repeated syringe punctures to draw tiny partial aliquots for neural cell culture testing.
Cedric L. –
Perfect material for cognitive and neuroprotective research. The acetate buffer effectively prevents peptide breakdown after reconstitution. I prepare small batches each time, and the mixed solution stays clear and stable for several days. All vials arrived safely with zero breakage during shipping.
Vesper K. –
Consistent ≥99% HPLC purity, strict low-temperature dark dry storage guidelines, uniform powder consistency and rock-solid cross-batch quality stability make SX5 my permanent exclusive Semax peptide supplier. I place monthly repeat orders for my long-term neurovascular, cognitive and neuroprotective lab research projects with zero fluctuations in purity or biological activity between restock shipments.