Description
Basic introduction
Semax is a synthetic heptapeptide based on an ACTH-derived fragment with a Pro-Gly-Pro extension. The XA5 and SX5 entries in this catalog are separate listings of the same named research compound, with their own available package options.
Preclinical studies have explored neurotrophin-related responses and gene expression in rodent brain preparations. These studies describe molecular and experimental endpoints; they are not evidence that a laboratory vial improves memory, mood or recovery in people.
Mechanism of action · Research context
ACTH-derived sequence
Semax is a defined seven-amino-acid peptide. Its relationship to an ACTH fragment provides a structural starting point, but should not be taken to mean that it reproduces all actions of intact ACTH.
BDNF-related responses
Rat hippocampal studies measured BDNF-related changes after Semax exposure. Researchers examined both transcript and protein-related endpoints, which capture different stages of a cellular response.
TrkB signaling
Neurotrophin signaling includes receptor activation as well as expression. The cited study examined TrkB phosphorylation, illustrating why an mRNA change alone is insufficient to characterize a signaling pathway.
Extended research considerations
Experimental context
Brain region, model and sampling time affect interpretation. A result from hippocampal tissue cannot automatically be assigned to every neuronal population or to a different injury model.
Sequence and batch comparison
Compare XA5 and SX5 by their actual documentation and selected package. Different catalog codes do not establish a biological difference, and identical names do not replace confirmation of batch identity.
Readout selection
Gene expression, protein abundance and functional behavior are distinct outcomes. A study plan should specify which of these it measures before interpreting a result as a broader neuronal effect.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 5 mg × 10 vials; 10 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at -20°C (Protect from light and moisture). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- Semax, BDNF and TrkB in rat hippocampal research
View report
Graham P. –
This bulk 10-vial pack offers great value on sale. Every vial has uniform white powder with no low-potency units. My experimental results stay consistent and repeatable from the first vial all the way to the last one.
Riven H. –
Semax is my core research compound for cerebral circulation, cognitive enhancement and neuroprotective mechanism studies. The built-in acetate buffer holds pH steady between 4.0–6.0 to slow peptide denaturation post-reconstitution, and reconstituted working solution stays transparent for multiple refrigerated testing days. All glass vials arrived fully intact with zero breakage during cross-border international lab shipping.
Rona Fenn –
Tested four Semax brands side-by-side, SX5 delivers the steadiest cerebral recovery curve data. Molecular parameters match lab reference databases, skipping compound identity verification. I only reconstitute one vial weekly to avoid diluted peptide waste.
Ewan Maeve –
The lyophilized white powder stays loose and free-flowing, never compacting into hard sediment at the bottle base. For quick preliminary neural screening assays, I take small dry powder samples instead of mixing the whole vial, cutting lab Semax waste nearly in half.
Sylvan C. –
Advanced industrial lyophilization technology creates ultra-fine free-flowing white powder with zero hard compacted chunks settled at the vial bottom. When I only require tiny micro-dose samples for early-stage preliminary screening assays, I can extract partial powder without fully reconstituting the entire vial to conserve expensive Semax stock.