Description
Basic introduction
MOTS-c is a 16-amino-acid peptide described in research on mitochondrial-derived signaling. Its sequence is associated with the mitochondrial 12S rRNA region, and early investigations examined cellular metabolism and mouse metabolic models.
A mitochondrial origin does not mean that every experimental effect occurs inside mitochondria. The research connects a defined peptide to broader metabolic measurements that depend on the biological model and study conditions.
Mechanism of action · Research context
Mitochondrial-derived sequence
MOTS-c is studied as a mitochondrial-derived peptide. Sequence confirmation provides the starting point for comparison with the material used in published experiments.
Metabolic pathway changes
Early studies examined folate and purine-related metabolism. These observations linked peptide exposure to changes in cellular metabolic pathways rather than establishing a single direct receptor mechanism.
AMPK-associated responses
AMPK-related signaling featured in the original research. Such signaling measurements should be considered alongside the measured metabolic phenotype rather than treated as a complete explanation of every effect.
Extended research considerations
Cellular metabolic assays
Specify whether the endpoint concerns metabolites, signaling or energy use. Different assay types capture different stages of the response and may not change in parallel.
Animal-model context
The original work included mouse metabolic experiments. Results from those models should remain distinct from claims about human exercise performance or weight management.
Comparative material quality
Compare the actual peptide sequence, content and analytical profile. Shared mitochondrial-research terminology does not make MOTS-c interchangeable with SS-31 or a cofactor such as NAD+.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 10 mg × 10 vials; 20 mg × 10 vials; 40 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at -20°C (Protect from light and moisture). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- Original MOTS-c metabolic research (Cell Metabolism, 2015)
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Rhys Davis –
Prolonged UV light exposure triggers gradual yellow discoloration and molecular breakdown of MOTS-C powder, so I store all unopened sealed vials inside fully opaque freezer storage bins. After two full months of uninterrupted -20°C frozen storage, the powder stays bright pure white, and reconstituted peptide liquid never develops cloudiness or solid precipitates over multi-day refrigerated testing cycles.
Rhys Kade –
A lab trainee accidentally left an unopened MS10 MOTS-C vial on the lab bench at room temperature for three full days. Post-testing revealed severe powder clumping and drastically weakened fat-burning mitochondrial activity, proving strict dark frozen -20°C storage rules are non-negotiable for long-term stock preservation.
Lavinia Eaton –
The provided CAS registry number, molecular formula and 2174.59 Da molecular weight match peer-reviewed biochemical reference databases perfectly. This lab-grade MS10 MOTS-C contains no inert bulking fillers or truncated peptide fragments, and steady -20°C dark storage stops UV-triggered oxidation that damages its mitochondrial signaling peptide structure.
Roxie Vale –
I ran blinded parallel metabolic cell trials with MOTS-C sourced from six different manufacturers, and this lyophilized MS10 variant delivers far more balanced solubility with minimal powder residue stuck to inner glass vial walls. Slow circular swirling achieves full dissolution; harsh violent shaking fractures the short peptide backbone and skews quantitative fat oxidation assay readouts.
Marlow Lane –
I perform random blind HPLC spot quality audits on randomly selected vials from every shipment batch. Every tested sample consistently hits the advertised ≥99% purity threshold with no unknown impurity peaks on chromatogram outputs. Complete batch purity certification documents ship with every order, fully compliant with university lab audit and academic manuscript submission standards.