Description
Basic introduction
Semax is a synthetic heptapeptide based on an ACTH-derived fragment with a Pro-Gly-Pro extension. The XA5 and SX5 entries in this catalog are separate listings of the same named research compound, with their own available package options.
Preclinical studies have explored neurotrophin-related responses and gene expression in rodent brain preparations. These studies describe molecular and experimental endpoints; they are not evidence that a laboratory vial improves memory, mood or recovery in people.
Mechanism of action · Research context
ACTH-derived sequence
Semax is a defined seven-amino-acid peptide. Its relationship to an ACTH fragment provides a structural starting point, but should not be taken to mean that it reproduces all actions of intact ACTH.
BDNF-related responses
Rat hippocampal studies measured BDNF-related changes after Semax exposure. Researchers examined both transcript and protein-related endpoints, which capture different stages of a cellular response.
TrkB signaling
Neurotrophin signaling includes receptor activation as well as expression. The cited study examined TrkB phosphorylation, illustrating why an mRNA change alone is insufficient to characterize a signaling pathway.
Extended research considerations
Experimental context
Brain region, model and sampling time affect interpretation. A result from hippocampal tissue cannot automatically be assigned to every neuronal population or to a different injury model.
Sequence and batch comparison
Compare XA5 and SX5 by their actual documentation and selected package. Different catalog codes do not establish a biological difference, and identical names do not replace confirmation of batch identity.
Readout selection
Gene expression, protein abundance and functional behavior are distinct outcomes. A study plan should specify which of these it measures before interpreting a result as a broader neuronal effect.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 5 mg × 10 vials; 10 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at -20°C (Protect from light and moisture). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- Semax, BDNF and TrkB in rat hippocampal research
View report
Daisie Oakley –
I design comparative dose-gradient neural cell trials to study neuropeptide synergy, and SX5’s consistent purity across all vial sizes eliminates potency shifts that corrupt comparison datasets. Test outputs collected from tiny dry powder scrapings align perfectly with data from full-vial reconstitution trials, saving me hours recalibrating lab testing hardware between batches.
Vada Quinton –
A new lab trainee placed an SX5 vial in a frost-free freezer compartment with frequent temperature fluctuations for 48 hours. Post-assay testing confirmed severe loss of biological activity, reinforcing strict rules for consistent dark, stable frozen storage. I printed detailed handling guidelines to post above the peptide storage shelf to prevent repeat errors.
Marigold T. –
UV light is the primary trigger for Semax molecular breakdown, so I store all unopened sealed vials inside fully opaque freezer storage bins. After three full months of unbroken frozen -20°C storage, the powder remains bright pure white with no yellowing, and reconstituted peptide liquid never develops cloudiness or solid precipitates over multi-day testing cycles.
Torran S. –
This 10-vial bulk pack comes with a steep limited-time promotional discount that significantly cuts my monthly lab raw material overhead. Vial-to-vial powder texture, concentration and purity show zero measurable deviation, making all my cerebral blood flow experimental data highly repeatable batch after batch.
Joren W. –
The optimized balanced acetate buffer blend drastically minimizes peptide adhesion to vial glass walls post-dissolution. I recover nearly 100% of the labeled 5mg lyophilized powder from every vial, removing major dosing inaccuracies in quantitative neurotransmitter and neurovascular signaling research.