Description
Basic introduction
Semax is a synthetic heptapeptide based on an ACTH-derived fragment with a Pro-Gly-Pro extension. The XA5 and SX5 entries in this catalog are separate listings of the same named research compound, with their own available package options.
Preclinical studies have explored neurotrophin-related responses and gene expression in rodent brain preparations. These studies describe molecular and experimental endpoints; they are not evidence that a laboratory vial improves memory, mood or recovery in people.
Mechanism of action · Research context
ACTH-derived sequence
Semax is a defined seven-amino-acid peptide. Its relationship to an ACTH fragment provides a structural starting point, but should not be taken to mean that it reproduces all actions of intact ACTH.
BDNF-related responses
Rat hippocampal studies measured BDNF-related changes after Semax exposure. Researchers examined both transcript and protein-related endpoints, which capture different stages of a cellular response.
TrkB signaling
Neurotrophin signaling includes receptor activation as well as expression. The cited study examined TrkB phosphorylation, illustrating why an mRNA change alone is insufficient to characterize a signaling pathway.
Extended research considerations
Experimental context
Brain region, model and sampling time affect interpretation. A result from hippocampal tissue cannot automatically be assigned to every neuronal population or to a different injury model.
Sequence and batch comparison
Compare XA5 and SX5 by their actual documentation and selected package. Different catalog codes do not establish a biological difference, and identical names do not replace confirmation of batch identity.
Readout selection
Gene expression, protein abundance and functional behavior are distinct outcomes. A study plan should specify which of these it measures before interpreting a result as a broader neuronal effect.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 5 mg × 10 vials; 10 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at -20°C (Protect from light and moisture). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- Semax, BDNF and TrkB in rat hippocampal research
View report
Lila Shepard –
Two sizes are available: 5mg for small pilot screening and 10mg for large mouse brain trials. The standard 5mg vial fits my daily small-scale cell culture perfectly. I reordered three bulk packs, every vial has the same strength with zero batch differences. The gold airtight cap stops moisture from seeping in even after many needle punctures in freezer storage.
Elena Vale –
My long-term cognitive aging trials run for months straight, every new SX5 shipment keeps identical purity and activity. The loose lyophilized powder never hardens into chunks at the vial bottom. I can scrape tiny dry powder bits for quick small tests without dissolving the whole 5mg vial to save raw materials.
Tristan Powell –
A student lab assistant accidentally left an unopened vial exposed under overhead lab lights for two full days; follow-up cell testing revealed a sharp drop in nerve repair capacity. After relocating all SX5 inventory into fully light-proof opaque freezer bins, my experiment repeatability metrics improved significantly. Competing peptide brands fail to clearly highlight Semax’s extreme photosensitivity risk.
Cedric Oakley –
I’ve restocked SX5 on a monthly basis for 10 consecutive months, and it is my exclusive Semax peptide source for all neuroprotection and cognitive aging research projects. Reliable ≥99% HPLC purity standards, explicit dark frozen storage instructions, two flexible vial sizing options, and consistent cross-batch potency resolved all unreliable assay data inconsistencies I encountered with competing low-quality peptide vendors.
Lila Shepard –
Two distinct vial sizes cover all my research workflows: 5mg for small-scale preliminary neural screening, and 10mg for full rodent cognitive aging trials. The standard 5mg vial perfectly matches my daily low-dose cell culture protocols. I’ve reordered three bulk packs, every single vial maintains identical biological activity with no cross-batch deviation. The gold hermetic cap locks out moisture reliably, even after dozens of needle punctures during freezer storage sampling.