Description
Basic introduction
IGF-1 LR3 is a modified insulin-like growth factor analog. Its sequence includes an N-terminal extension and an amino-acid substitution, distinguishing it from native IGF-1 and making molecular identity an important part of the specification.
The research context includes receptor-mediated cellular responses and interactions with IGF-binding proteins. Binding proteins, assay medium and cell type can all influence the response, so the analog should not be described as a universally stronger version of native IGF-1.
Mechanism of action · Research context
IGF receptor context
IGF-1 LR3 is investigated through IGF-related receptor responses. A receptor assay provides a defined functional endpoint, separate from growth, differentiation or survival measured in a complete cell preparation.
Binding-protein interaction
The analog has altered interactions with IGF-binding proteins. Primary granulosa-cell research compared native IGF-1 and analogs in the presence of binding proteins, demonstrating the importance of the surrounding experimental system.
Medium-dependent response
The available fraction depends on the assay environment. Different binding-protein conditions can change a comparison between analogs without changing the identity of the compounds being tested.
Extended research considerations
Growth and viability readouts
Cell number, proliferation markers and survival measure different responses. Separating them helps avoid interpreting a larger final cell population as evidence for one particular signaling mechanism.
Structural characterization
Confirm the extended sequence and expected molecular identity. The LR3 designation and a purity percentage alone do not establish correct folding or functional receptor activity.
Solution compatibility
Use material-specific compatibility evidence for the intended assay. A generic acidic-solvent recommendation cannot establish recovery or activity across all protein preparations and media.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 0.1 mg × 10 vials; 1 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at 20°C to 25°C (Do not freeze). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- IGF analogs and binding proteins in granulosa-cell research
View report
Rhea X. –
Stable ≥99% HPLC purity, convenient room-temperature storage rules, two flexible dosage sizes and steady cross-batch consistency make this IG1 my exclusive IGF-1 LR3 supply. I reorder monthly for my long-term tissue regeneration research with zero quality complaints across all shipments.
Quentin W. –
The lyophilization process creates ultra-fine uniform powder without large hard chunks inside vials. If I only need a tiny micro-dose for preliminary screening, I can extract small amounts without having to fully reconstitute the whole vial and waste protein.
Una Quinton –
The listed CAS registry number, molecular formula and massive 9117.50 Da molecular weight align perfectly with authoritative peer-reviewed biochemical reference datasheets. This lab-grade IG1 IGF-1LR3 contains no inert bulking fillers or fragmented peptide fragments, and consistent 20–25°C dark storage blocks photo-oxidation that degrades its growth-factor active peptide structure.
Violet Rhea –
I ran blinded parallel myogenesis cell trials with IGF-1LR3 sourced from six different manufacturers, and this acetate co-lyophilized IG1 variant delivers unmatched solubility with barely any powder residue sticking to inner glass vial walls. Slow circular swirling achieves full dissolution; harsh vigorous shaking fractures the large peptide backbone and invalidates quantitative muscle proliferation assay readouts.
Dottie W. –
Potency is uniform across all 10 vials in this pack. The powder dissolves fully into a clear solution with zero sediment. The airtight vials keep out moisture well, so there is no clumping even with long-term storage at room temperature.