Description
Basic introduction
IGF-1 LR3 is a modified insulin-like growth factor analog. Its sequence includes an N-terminal extension and an amino-acid substitution, distinguishing it from native IGF-1 and making molecular identity an important part of the specification.
The research context includes receptor-mediated cellular responses and interactions with IGF-binding proteins. Binding proteins, assay medium and cell type can all influence the response, so the analog should not be described as a universally stronger version of native IGF-1.
Mechanism of action · Research context
IGF receptor context
IGF-1 LR3 is investigated through IGF-related receptor responses. A receptor assay provides a defined functional endpoint, separate from growth, differentiation or survival measured in a complete cell preparation.
Binding-protein interaction
The analog has altered interactions with IGF-binding proteins. Primary granulosa-cell research compared native IGF-1 and analogs in the presence of binding proteins, demonstrating the importance of the surrounding experimental system.
Medium-dependent response
The available fraction depends on the assay environment. Different binding-protein conditions can change a comparison between analogs without changing the identity of the compounds being tested.
Extended research considerations
Growth and viability readouts
Cell number, proliferation markers and survival measure different responses. Separating them helps avoid interpreting a larger final cell population as evidence for one particular signaling mechanism.
Structural characterization
Confirm the extended sequence and expected molecular identity. The LR3 designation and a purity percentage alone do not establish correct folding or functional receptor activity.
Solution compatibility
Use material-specific compatibility evidence for the intended assay. A generic acidic-solvent recommendation cannot establish recovery or activity across all protein preparations and media.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 0.1 mg × 10 vials; 1 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at 20°C to 25°C (Do not freeze). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- IGF analogs and binding proteins in granulosa-cell research
View report
Paisley V. –
This IGF-1 LR3 works well for more than basic anti-aging studies. I also use it for muscle cell differentiation in-vitro trials, and the consistent acetate buffer pH eliminates the need to add extra neutralizing agents to my culture media mixes.
Faye Y. –
Molecular weight perfectly matches the listed value. This research-grade product has no fillers or extra impurities. As long as I avoid freezing, the peptide activity stays consistent month after month with no loss of strength.
Clayton V. –
This IGF-1 LR3 is high-quality white lyophilized powder with acetate buffer. HPLC testing verified purity above 99%. The pH stays stable between 4.0–6.0. I keep the vials between 20–25°C without freezing, and the peptide maintains full potency without degradation.
Orin U. –
The shipping packaging uses individual foam dividers for each glass vial to avoid collision damage. I’ve ordered three international bulk shipments so far, and zero vials arrived cracked, leaking or contaminated during long transit times.
Freya L. –
This long-chain IGF protein is indispensable for my cellular repair and anti-aging lab research. The built-in acetate buffer holds pH between 4.0–6.0, which effectively slows protein unfolding once reconstituted with solvent. Every glass vial arrived fully sealed and undamaged after cross-border shipping.