Description
Basic introduction
IGF-1 LR3 is a modified insulin-like growth factor analog. Its sequence includes an N-terminal extension and an amino-acid substitution, distinguishing it from native IGF-1 and making molecular identity an important part of the specification.
The research context includes receptor-mediated cellular responses and interactions with IGF-binding proteins. Binding proteins, assay medium and cell type can all influence the response, so the analog should not be described as a universally stronger version of native IGF-1.
Mechanism of action · Research context
IGF receptor context
IGF-1 LR3 is investigated through IGF-related receptor responses. A receptor assay provides a defined functional endpoint, separate from growth, differentiation or survival measured in a complete cell preparation.
Binding-protein interaction
The analog has altered interactions with IGF-binding proteins. Primary granulosa-cell research compared native IGF-1 and analogs in the presence of binding proteins, demonstrating the importance of the surrounding experimental system.
Medium-dependent response
The available fraction depends on the assay environment. Different binding-protein conditions can change a comparison between analogs without changing the identity of the compounds being tested.
Extended research considerations
Growth and viability readouts
Cell number, proliferation markers and survival measure different responses. Separating them helps avoid interpreting a larger final cell population as evidence for one particular signaling mechanism.
Structural characterization
Confirm the extended sequence and expected molecular identity. The LR3 designation and a purity percentage alone do not establish correct folding or functional receptor activity.
Solution compatibility
Use material-specific compatibility evidence for the intended assay. A generic acidic-solvent recommendation cannot establish recovery or activity across all protein preparations and media.
Material and packaging
Listed appearance: White Lyophilized Powder.
Available kit specifications: 0.1 mg × 10 vials; 1 mg × 10 vials. Select an option above to view its current price and availability.
Storage and handling
Source-listed storage condition: Store at 20°C to 25°C (Do not freeze). Follow the handling instructions supplied with the actual batch and your laboratory's procedures.
Analytical documentation
Reference analytical documents are available with this listing. Check the material identity, batch number and test date against the batch supplied; contact us for current batch documentation.
Scientific references
These publications describe the studied molecules and experimental models. They do not certify the identity, quality or effects of a particular supplied batch.
- IGF analogs and binding proteins in granulosa-cell research
View report
Elias K. –
All vials inside the 10-unit bulk pack have consistent fine lyophilized powder with zero clumping right out of the box. It dissolves rapidly into fully transparent liquid without any floating protein aggregates. The tight gold crimp cap creates a moisture-proof seal, so humidity won’t ruin the powder after repeated punctures for sampling.
Seth Rowe –
IGF-1LR3 acts as my core research peptide for muscle cell differentiation, insulin sensitivity and skeletal muscle hypertrophy pathway studies. The integrated acetate buffer locks pH steadily between 4.0–6.0 to slow peptide denaturation post-reconstitution, and mixed working peptide solution stays transparent for multiple refrigerated testing cycles. All glass vials arrived fully intact with zero breakage during cross-border international lab shipping.
Daisy J. –
This IGF-1 LR3 is white acetate-buffered lyophilized protein powder with HPLC purity over 99%. Unlike other long-chain peptides that need frozen storage, this variant only requires stable 20–25°C ambient storage and must never be frozen to avoid irreversible protein denaturation. Stored in a dark cabinet, the powder stays uniform white for weeks without discoloration.
Briar Maeve –
This 10-vial bulk pack includes a steep limited-time promotional markdown that drastically cuts my monthly lab raw material procurement overhead. Vial-to-vial powder texture, peptide concentration and HPLC purity show zero measurable deviation, making all my muscle regeneration experimental data highly repeatable across separate test batches.
Ruth Maeve –
Each vial inside the standard 1mg×10 bulk kit holds ultra-fine free-flowing white lyophilized powder that dissolves fully into sediment-free crystal clear liquid after slow gentle swirling. The airtight gold aluminum flip cap creates a full humidity barrier, so powder never clumps even after repeated syringe punctures to draw tiny partial aliquots for myoblast cell culture testing.